| Course label : | Applied molecular spectroscopy - Part I |
|---|---|
| Teaching departement : | CMA / |
| Teaching manager : | Mister VANGELIS AGOURIDAS |
| Education language : | |
| Potential ects : | 0.0 |
| Results grid : | |
| Code and label (hp) : | ENSCL_CI_M5_2_2 - Chimie & str. état sol. |
Education team
Teachers : Mister VANGELIS AGOURIDAS / Mister ERIC BUISINE
External contributors (business, research, secondary education): various temporary teachers
Summary
On the basis of fundamental knowledges necessary for a good understanding of the one-dimensional 1H and 13C Nuclear Magnetic Resonance (NMR) spectra, being able to determine the structures and the properties (chemical shifts and coupling constants) of small organic molecules at liquid state.
Educational goals
Knowledge: Knowing the basics theory of 1D NMR for 1H and 13C nuclei, Skills: - Interpretation of 1H and 13C NMR spectra of small organic molecules (solution, liquid state), - Identification of groups of chemically and magnetically equivalent nuclei, - Recognition of homotopic, enantiotopic and diasterotopic nucleii, - Analysis of first-order and second-order spin-spin coupling systems, - Determination of J coupling constants for first-order coupling systems, - Analysis of nuclei chemical shifts in terms of surrounding in the molecule: magnetic anisotropy and electronic (inductive and mesomeric) effects.
Sustainable development goals
Knowledge control procedures
Continuous Assessment
Comments:
Online resources
copy of presentations are accessible from the intranet
Pedagogy
PowerPoint presentations 20 hours dedicated to lecture & 14 hours to tutorials Taught in french
Sequencing / learning methods
| Number of hours - Lectures : | 16 |
|---|---|
| Number of hours - Tutorial : | 16 |
| Number of hours - Practical work : | 8 |
| Number of hours - Seminar : | 0 |
| Number of hours - Half-group seminar : | 0 |
| Number of student hours in TEA (Autonomous learning) : | 3 |
| Number of student hours in TNE (Non-supervised activities) : | 0 |
| Number of hours in CB (Fixed exams) : | 0 |
| Number of student hours in PER (Personal work) : | 0 |
| Number of hours - Projects : | 0 |
Prerequisites
Basic competences acquired during previous formations (CPGE, CPI, DEUG, DUT, BTS, ATS).
Maximum number of registrants
Remarks
Lesson plan: Chapter I - Introduction: NMR active nuclei ; energy and magnetic/spin states of nuclei in organic molecules ; spin transition and magnetic resonance frequency ; macroscopic magnetization ; basic pulsed NMR principles; the signal in pulsed NMR (FID); relaxation mechanisms ; Fourier Transform of the NMR signal ; intensity of NMR signals and quantitative analysis ; introduction to 13C NMR spectroscopy (NOE effects, 1H decoupling technique). Chapter II - Chemical Shift: definition ; shielding constant ; shielding and deshielding effects ; magnetic anisotropy of molecules ; chemical shifts of typical 1H and 13C nuclei in organic molecules ; influence of conformational and chemical exchanges. Chapter III - Scalar spin-spin coupling: polarization mechanisms ; scalar coupling energy ; coupling and chemical structure ; typical 1H-1H homonuclear coupling constants (geminal, vicinal, long-range) ; coupling of 1H nuclei bound to heteroatoms ; chemical equivalence ; magnetic equivalence ; stereotopic protons (homotopic, enantiotopic, diastereotopic); first- and second-order scalar coupling systems.