| Course label : | Heterocyclic chemistry |
|---|---|
| Teaching departement : | CMA / |
| Teaching manager : | Mister ERIC BUISINE |
| Education language : | |
| Potential ects : | 0 |
| Results grid : | |
| Code and label (hp) : | ENSCL_CI_M7_1_1_1 - Chimie hétérocylique |
Education team
Teachers : Mister ERIC BUISINE
External contributors (business, research, secondary education): various temporary teachers
Summary
The course covers the synthesis and the reactivity of the five-membered aromatic heterocycles (pyrrole and imidazole) and six-membered ring (pyridine). An access is put on the implication of these heterocycles in the enzymatic systems (role of the imidazole (histidine) in the mechanism of action of a protease, role of the pyridine in the oxido-reduction mechanisms involved the NAD(P) + / NAD(P)H systems). Tutorial classes are based on examples of synthesis of drugs (metronidazole, cerivastatine, atorvastatine) or of molecules with relevant biological activity (pyridoxal, porphyrinic motif)
Educational goals
It is a course of heterocyclic chemistry which aims at bringing a basic competence on the reactivity and the synthesis of simple aromatic heterocycles
Sustainable development goals
Knowledge control procedures
Continuous Assessment
Comments: Written test (1h), questions on the curse and exercises
Online resources
The Chemistry of Heterocycles: Structure, Reactions, Syntheses, and Applications, Second Edition, Author(s): Professor Dr. Theophil Eicher, Professor Dr. Siegfried Hauptmann, PD Dr. Andreas Speicher, Copyright ￜ 2003 Wiley-VCH Verlag GmbH & Co. KGaA, Print ISBN: 9783527307203
Pedagogy
Slideshow course + handout (introduction chapter) Blackboard course (chapters on heterocycles addressed) and TD in direct relation with the concepts discussed
Sequencing / learning methods
| Number of hours - Lectures : | 8 |
|---|---|
| Number of hours - Tutorial : | 4 |
| Number of hours - Practical work : | 0 |
| Number of hours - Seminar : | 0 |
| Number of hours - Half-group seminar : | 0 |
| Number of student hours in TEA (Autonomous learning) : | 0 |
| Number of student hours in TNE (Non-supervised activities) : | 0 |
| Number of hours in CB (Fixed exams) : | 0 |
| Number of student hours in PER (Personal work) : | 0 |
| Number of hours - Projects : | 0 |
Prerequisites
Organic chemistry L3 level : Notions of aromaticity, electrophilic and nucleophilic aromatic substitutions, chemistry of the carbonyl function, of compounds with reactive methylene.